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In conclusion, top TiO2 factories play a crucial role in meeting the global demand for high-quality titanium dioxide products. Companies like DuPont, Kronos, Tronox, and Tayca are leading the way with their superior quality products and innovative technology, making them top choices for manufacturers seeking top-quality TiO2 pigments. By investing in research and development and adopting sustainable practices, these top TiO2 factories continue to set new standards for quality and performance in the industry, driving innovation and growth in the global TiO2 market.

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While IARC listed titanium dioxide as “possibly carcinogenic to humans,” they also add that “there is inadequate evidence in humans for the carcinogenicity of titanium dioxide.” Of the four human studies that they reviewed, only one showed a potential risk for occupational workers inhaling titanium dioxide particles and lung cancer, while the other three showed no risk for cancer at all. And it’s key to note that IARC did not assess the effects of titanium dioxide found in foods.

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The aim of this work was to examine particularly the Degussa P25 titanium dioxide nanoparticles (P25TiO2NPs) because they are among the most employed ones in cosmetics. In fact, all kinds of titanium dioxide nanoparticles (TiO2NPs) have gained widespread commercialization over recent decades. This white pigment (TiO2NPs) is used in a broad range of applications, including food, personal care products (toothpaste, lotions, sunscreens, face creams), drugs, plastics, ceramics, and paints. The original source is abundant in Earth as a chemically inert amphoteric oxide, which is thermally stable, corrosion-resistant, and water-insoluble. This oxide is found in three different forms: rutile (the most stable and substantial form), brookite (rhombohedral), and anatase (tetragonal as rutile), of these, both rutile and anatase are of significant commercial importance in a wide range of applications [3]. Additionally, the nano-sized oxide exhibits interesting physical properties, one of them is the ability to act as semiconducting material under UV exposure. In fact, TiO2NPs are the most well-known and useful photocatalytic material, because of their relatively low price and photo-stability [4]. Although, this photoactivity could also cause undesired molecular damage in biological tissues and needs to be urgently assessed, due to their worldwide use. However, not all nanosized titanium dioxide have the same behavior. In 2007, Rampaul A and Parkin I questioned: “whether the anatase/rutile crystal form of titanium dioxide with an organosilane or dimethicone coat, a common titania type identified in sunscreens, is appropriate to use in sunscreen lotions” [5]. They also suggested that with further study, other types of functionalized titanium dioxide could potentially be safer alternatives. Later, Damiani found that the anatase form of TiO2NPs was the more photoactive one, and stated that it should be avoided for sunscreen formulations, in agreement with Barker and Branch (2008) [6,7].

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The inception and evolution of lithopone can be traced back through various industries and diverse applications. Revered for its robust hiding power, this white pigment, also called sulfide of zinc white, has been an invaluable asset to industries requiring a durable and reliable white pigment. Lithopone was an economical and functional solution as an alternative to lead carbonate, which is prone to change, and zinc oxide, known for its brittleness.

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